In such cases where there are no small molecule agonists to a protein, a CPP can be used as therapy. The CPP will penetrate the cell membrane and elicit an agonist response directly on the signaling pathway. The company has synthesized CPP mimics of the GLP-1, Angiotensin II1A, CGRP and Dopamine D2 receptors, all with in vitro results confirming the validity of the principle.Another class of proteins which are mimicked by protein derived CPPs is Transcription Factors. By this technology, i.e. by selecting signalling of specific Transcription Factors, it is possible to regulate tumour proliferation and apoptosis.
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